Korean Personal Genome Project (KPGP): http://kpgp.kr
- Korean Personal Genome Project (KPGP) is a participative research project established by Genome Research Foundation (GRF), Korea. The international Personal Genome Project (PGP), led by U.S. none-profit research group, was found in 2006 and seeking a diverse range of volunteers with a purpose of improving human health. In concordance with the international PGP, KPGP started to improve Korean people's health and medical welfare. KPGP is a daughter project of KGP (Korean Genome Project)
KPGP is seeking for scientific research that can promote happy and healthy life style by using genome technology.
- to build Korean standard genetic information database
- to enable the participative genome research
- to develop genome sequencing and analysis technologies in the era of personal genetic information services
- to prepare open community for ethical, social and legal issues related to genetic information
Korean reference genome project
Rare diseases reference genome project
HLA alleles reference standard data production project
- Genetic Information Participation
- Consist of public participation and determine whether or not to participate through human genetics education, screening and participant`s willingness.
- Research Participation
- People who have research experience in the field of human genetics, or who can contribute to KPGP could participate through screening.
- Company Participation
- Institutes and companies could participate. Sponsorship can greatly help KPGP`s activation.
- OPEN KPGP
- Human genome researches have developed rapidly since the human genome project was completed in 2003. Recently large-scale production of human genome data is available with the advent of Next Generation Sequencing (NGS).
Genome Research Foundation (GRF), as a non-profit foundation, determined to open Korean genome data and the current available data of human genome sequence and analysis for free to allow researchers to study. Under the circumstances, OPEN KPGP started on 2011.
The first Korean genome sequence and analysis: Full genome sequencing for a socio-ethnic group
Sung-Min Ahn, Tae-Hyung Kim, Sunghoon Lee, et al. Genome Res. published online May 26, 2009
We present the first Korean individual genome sequence (SJK) and analysis results. The diploid genome of a Korean male was sequenced to 28.95-fold redundancy using the Illumina paired-end sequencing method. SJK covered 99.9% of the NCBI human reference genome. We identified 420,083 novel single nucleotide polymorphisms (SNPs) that are not in the dbSNP database. Despite a close similarity, significant differences were observed between the Chinese genome (YH), the only other Asian genome available, and SJK: (1) 39.87% (1,371,239 out of 3,439,107) SNPs were SJK-specific (49.51% against Venter’s, 46.94% against Watson’s, and 44.17% against the Yoruba genomes); (2) 99.5% (22,495 out of 22,605) of short indels (< 4 bp) discovered on the same loci had the same size and type as YH; and (3) 11.3% (331 out of 2920) deletion structural variants were SJK-specific. Even after attempting to map unmapped reads of SJK to unanchored NCBI scaffolds, HGSV, and available personal genomes, there were still 5.77% SJK reads that could not be mapped. All these findings indicate that the overall genetic differences among individuals from closely related ethnic groups may be significant. Hence, constructing reference genomes for minor socio-ethnic groups will be useful for massive individualgenome sequencing.
[Supplemental material is available online at www.genome.org. The sequence data from this study are available at ftp://ftp.kobic.kr/pub/KOBIC-KoreanGenome/ and have been deposited in the NCBI Short Read Archive (http://www.ncbi.nlm.nih.gov/Traces/sra/sra.cgi) under accession no. SRA008175.]